Creatine supplementation is approved by professional sports federations such as the International Olympic Committee and the National Collegiate Athletics Association (NCAA). They are also available as over-the-counter vitamins and medicines in grocery stores. The most commonly used is creatine monohydrate, a dietary supplement which increases muscle performance during long-term, high-intensity resistance exercises.

Over the years, the number of men who take testosterone supplements has dramatically increased. Debates have come out as to whether it is safe or not. Most of these T booster supplements will likely only have noticeable benefits in individuals with fertility issues or low testosterone levels. Some also appear to benefit athletes or dieters, who often experience significant decreases in testosterone due to oxidative stresss.